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Updated: Jul 31, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
Neuroleptic medication for dystonia. Reciprocal relationship between effects on motor function and mood
C S Young1, J B Stewart, G W Fenton
1Department of Psychiatry, Royal Dundee Liff Hospital.
Background:
The presence of dysphoric symptoms associated with neuroleptic medication is commonly reported.
Method:
Neuroleptic treatment of a segmental dystonia resulted in a disabling depressive illness, which when treated with antidepressants led to the return of the involuntary movements.
Results:
The use of several different antidepressants and neuroleptics confirmed the association between drugs and symptoms. Genetic studies excluded "poor metaboliser status" as a reason for the patient's sensitivity to these drugs.
Conclusions:
The case illustrates a delicate imbalance between dose of neuroleptic medication and depressive symptoms. We should be aware of the possibility of mood changes in patients treated with neuroleptics for a variety of conditions.
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