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Abstract:
The structure of drug resistance was studied on 2788 clinical strains of staphylococci isolated from various materials of patients with purulent-inflammatory processes, stuff and environment within 12 years from 1968 to 1973. The number of staphylococci resistant to tetracycline increased 13 times among the cultures with resistance marker, while the number of staphylococci resistant to penicillin decreased 1-8 times. The study of the complex resistance revealed the predominance of staphylococci with tetracycline resistance structure (60-5 percent).
Insights
Over a 12-year period, tetracycline-resistant staphylococci increased significantly, while penicillin resistance declined. Tetracycline resistance predominated in complex resistance patterns.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Staphylococci are significant human pathogens causing purulent-inflammatory processes.
- Understanding antimicrobial resistance patterns is crucial for effective treatment.
- Historical data on staphylococcal resistance is vital for tracking trends.
Purpose of the Study:
- To analyze the trends in drug resistance among staphylococcal strains over a 12-year period.
- To investigate the prevalence of resistance to specific antibiotics, namely penicillin and tetracycline.
- To characterize complex drug resistance structures in staphylococci.
Main Methods:
- Analysis of 2788 clinical staphylococcal strains isolated from patients and the environment.
- Data collection spanning 12 years (1968-1973).
- Assessment of resistance markers for penicillin and tetracycline.
Main Results:
- A 13-fold increase in staphylococci resistant to tetracycline was observed.
- A decrease in staphylococci resistant to penicillin (1-8 times) was noted.
- Staphylococci exhibiting tetracycline resistance predominated in complex resistance structures (60.5%).
Conclusions:
- Significant shifts in staphylococcal antibiotic resistance occurred between 1968 and 1973.
- Tetracycline resistance emerged as a major concern, surpassing penicillin resistance.
- The findings highlight the dynamic nature of antimicrobial resistance in staphylococci.