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Bone disease in calcium stone forming patients
I P Heilberg1, L A Martini, V L Szejnfeld
1Nephrology Division, Escola Paulista de Medicina, São Paulo, Brasil.
Clinical Nephrology
|September 1, 1994
Summary
Idiopathic hypercalciuria is linked to osteopenia, particularly in men with fasting hypercalciuria. Calcium intake did not correlate with bone density loss in these patients.
Area of Science:
- Nephrology
- Endocrinology
- Bone Metabolism
Background:
- Idiopathic hypercalciuria (IH) is increasingly associated with osteopenia (OP).
- The role of dietary calcium in IH-related bone loss remains unclear.
- This study investigates the relationship between IH subtypes and bone mineral density (BMD).
Purpose of the Study:
- To assess the prevalence of osteopenia in patients with absorptive hypercalciuria (AH) and fasting hypercalciuria (FH).
- To determine if calcium intake correlates with bone mineral density in these patients.
- To characterize bone abnormalities in male FH patients with osteopenia.
Main Methods:
- Dual photon absorptiometry for BMD measurement in 55 IH patients (29 males, 26 premenopausal females).
- 72-hour dietary records to assess calcium intake.
- Bone histomorphometry with tetracycline double labeling in six osteopenic male FH patients.
Main Results:
- Osteopenia detected in 20% of IH patients, more prevalent in males (35%) than females (7%).
- Male FH patients showed significantly lower BMD compared to controls.
- Histomorphometry revealed low bone volume, increased resorption, and mineralization defects in male FH patients.
Conclusions:
- Idiopathic hypercalciuria, especially FH, is associated with osteopenia and altered bone remodeling.
- Calcium intake does not appear to be a critical factor in bone loss in this population.
- Findings suggest a complex interplay of factors contributing to osteoporosis in IH patients.