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[Candida infection in surgery]

M Naef1, J von Overbeck, C Seiler

  • 1Universitätsklinik für Viszerale und Transplantationschirurgie, Inselspital, Bern.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|September 1, 1994
PubMed
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Candida sepsis is a rare but deadly infection in surgical patients. Key risk factors include broad-spectrum antibiotics and invasive monitoring, with mortality linked to older age and organ failure.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Surgical Infections

Context:

  • Candida sepsis presents a rare but highly lethal challenge in surgical patient populations.
  • Diagnosis typically relies on positive blood cultures or direct fungal evidence in sterile sites.
  • Established risk factors include broad-spectrum antibiotics, invasive monitoring, immunocompromise, and surgical procedures.

Purpose:

  • To investigate the incidence and risk factors of Candida sepsis in a surgical cohort.
  • To analyze patient characteristics, treatment outcomes, and mortality associated with Candida sepsis.
  • To discuss therapeutic strategies, including antifungal prophylaxis and selective bowel decontamination.

Summary:

  • A retrospective review of 22,740 surgical patients (1987-1992) identified 11 cases of Candida sepsis.

Related Experiment Videos

  • Confirmed risk factors were universal for broad-spectrum antibiotics and invasive monitoring, alongside post-operative status and nasogastric intubation.
  • A 27% mortality rate was observed, with a higher fatality in patients experiencing multiple organ system failure.

    • Impact:

    • Reinforces the critical role of identified risk factors in the development of Candida sepsis.
    • Highlights the association between advanced age, organ failure, and increased mortality in these patients.
    • Informs clinical practice regarding antifungal treatment, prophylaxis, and decontamination strategies for surgical patients at risk.