Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The horse feto-placental unit

E Möstl1

  • 1Institut für Biochemie, Veterinärmedizinische Universität Wien, Osterreich.

Experimental and Clinical Endocrinology
|January 1, 1994
PubMed
Summary

The pregnant mare placenta produces two distinct estrogen groups. One group originates from fetal dehydroepiandrosterone, while the other derives from farnesyl pyrophosphate via a non-cholesterol pathway.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heart rate and salivary cortisol concentrations in foals at birth.

Veterinary journal (London, England : 1997)·2015
Same author

Reduced-size microchips for identification of horses: response to implantation and readability during a six-month period.

The Veterinary record·2013
Same author

Physiological and behavioral stress parameters in calves in response to partial scrotal resection, orchidectomy, and Burdizzo castration.

Journal of dairy science·2013
Same author

Configuration of antibodies for assay of urinary cortisol in dogs influences analytic specificity.

Domestic animal endocrinology·2013
Same author

Measurement of fecal glucocorticoid metabolites and evaluation of udder characteristics to estimate stress after sudden dry-off in dairy cows with different milk yields.

Journal of dairy science·2013
Same author

Pain management with flunixin meglumine at dehorning of calves.

Journal of dairy science·2012

Area of Science:

  • Reproductive endocrinology
  • Equine placental metabolism
  • Steroidogenesis

Background:

  • The placenta in pregnant mares synthesizes multiple estrogen types.
  • Estrogen production is crucial for maintaining pregnancy.
  • Understanding equine estrogen synthesis pathways is vital for reproductive health.

Purpose of the Study:

  • To elucidate the distinct biosynthetic origins of the two major estrogen groups in pregnant mares.
  • To differentiate the precursors and pathways involved in equine placental estrogen production.

Main Methods:

  • Analysis of estrogen precursors in placental tissues.
  • Tracing metabolic pathways of steroidogenesis in equine pregnancy.
  • Identification of key enzymes and intermediates in estrogen synthesis.

Main Results:

  • "Classical" estrogens (oestrone, oestradiol-17 beta, oestradiol-17 alpha) are derived from dehydroepiandrosterone originating from fetal gonads.
  • Ring B unsaturated estrogens (equilin, equilenin, and derivatives) are synthesized from farnesyl pyrophosphate through a pathway independent of cholesterol.

Conclusions:

  • The pregnant mare placenta utilizes two separate pathways for estrogen biosynthesis.
  • Fetal gonadal precursors supply classical estrogens, while a distinct pathway generates unsaturated estrogens.
  • These findings enhance our understanding of equine reproductive physiology and steroid hormone production.

Related Experiment Videos