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Updated: Feb 9, 2026

Transuterine Fetal Tracheal Occlusion Model in Mice
Published on: February 5, 2021
Gestagens in peripheral, uterine, ovarian and fetal blood in cows near term
1Department of Obstetrics, Faculty of Veterinary Medicine, Academy of Agriculture and Technology, Olsztyn, Poland.
Abstract:
The aim of this study was to determine if bovine placenta is capable of producing the gestagen metabolites in vivo. The concentrations of 5 beta-pregnane-3 alpha-20 alpha-diol, 17 alpha,20 alpha-dihydroxyprogesterone and progesterone were measured by HPLC-RIA in samples obtained after surgical preparation from peripheral, uterine, fetal and ovarian blood of seven cows near term. Measurement of arterio-venous differences in maternal uterine and umbilical circulation confirmed the placental origin of 5 beta-pregnance-3 alpha,20 alpha-diol and 17 alpha,20 alpha-dihydroxyprogesterone, but not progesterone itself. 5 beta-pregnane-3 alpha,20 alpha-diol was preferentially secreted into the fetal compartment. The present experiment, according to earlier in-vitro studies, confirms that the preterm bovine placenta is qualified for in-vivo utilization and secretion of gestagen metabolites.
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