Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue iso-renins

D Ganten, J S Hutchinson, H Haebara

    Clinical Science and Molecular Medicine. Supplement
    |December 1, 1976
    PubMed
    Summary

    Extrarenal tissues possess enzymes similar to kidney renin, suggesting a local role in biological functions. These tissue iso-renins are part of a complex enzyme system, particularly noted in the brain and adrenal gland.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers.

    Genomics·2000
    Same author

    Reduced cardiac hypertrophy and altered blood pressure control in transgenic rats with the human tissue kallikrein gene.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2000
    Same author

    Angiotensin peptides acting at rostral ventrolateral medulla contribute to hypertension of TGR(mREN2)27 rats.

    Physiological genomics·2000
    Same author

    Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects.

    Kidney international·2000
    Same author

    Gluco- and mineralocorticoid receptor-mediated regulation of neurotrophic factor gene expression in the dorsal hippocampus and the neocortex of the rat.

    The European journal of neuroscience·2000
    Same author

    Effect of bosentan on NF-kappaB, inflammation, and tissue factor in angiotensin II-induced end-organ damage.

    Hypertension (Dallas, Tex. : 1979)·2000

    Area of Science:

    • Biochemistry
    • Physiology
    • Enzymology

    Background:

    • Kidney renin plays a crucial role in the renin-angiotensin system.
    • The existence and function of renin-like enzymes in extrarenal tissues remain incompletely understood.

    Purpose of the Study:

    • To investigate the presence and characteristics of renin-like enzymes in extrarenal tissues.
    • To elucidate the potential biological functions of these tissue iso-renins.

    Main Methods:

    • Enzyme assays were performed on various extrarenal tissues.
    • Substrate specificity and physicochemical properties of tissue enzymes were compared to kidney renin.

    Main Results:

    • Several extrarenal tissues contain enzymes exhibiting renin-like activity, hydrolyzing angiotensinogen to angiotensin I.
    • These tissue iso-renins share similar substrate specificity and physicochemical properties with kidney renin.
    • Evidence suggests a complex, primarily local function for tissue iso-renins, with roles indicated in brain, adrenal gland, and tissue culture.

    Conclusions:

    • Extrarenal tissues harbor renin-like enzymes with properties akin to kidney renin.
    • Tissue iso-renins are integral components of localized enzymatic systems.
    • These findings highlight potential novel biological roles for iso-renins in specific organs and experimental models.

    Related Experiment Videos