[Ambiguity of translation: a eukaryotic version?]

In this review, the results of studies on genetic control of translation in the yeasts are considered and analyzed. The studies were performed on the system of the SUP35(SUP2) and SUP45(SUP1) genes. Based on data from genetic analysis, the study of protein synthesis in mutants at these genes, sequencing of both genes, deletion analysis of their functions, and the discovery of homologues of these genes in other eukaryotes, it may be assumed that the gene system under study is a specific evolutionarily conservative system for eukaryotes. This system not only controls translational fidelity, but also ensures integration of translation with other cellular processes.