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Published on: August 31, 2015
Inhibition of myeloperoxidase release from rat polymorphonuclear leukocytes by a series of azachalcone derivatives
M L Edwards1, D M Stemerick, J S Sabol
1Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.
Journal of Medicinal Chemistry
|December 9, 1994
Abstract:
A series of azachalcones was evaluated for ability to affect secretion of myeloperoxidase by rat polymorphonuclear leukocytes stimulated by fMLP. The compounds were found to interfere with cellular uptake of extracellular calcium. Structure-activity relationships are discussed.
