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Related Experiment Videos

Syringomyelia: clinical observations and experimental studies

P W Madsen1, R P Yezierski, V R Holets

  • 1Miami Project to Cure Paralysis, University of Miami School of Medicine, Florida.

Journal of Neurotrauma
|June 1, 1994
PubMed
Summary

Diagnosing spinal cord syringomyelia is now possible with advanced imaging. However, a lack of understanding of its pathology hinders effective treatment development, necessitating better animal models.

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Area of Science:

  • Neurology
  • Pathology
  • Medical Imaging

Background:

  • Spinal cord syringomyelia, characterized by cystic lesions, has been historically recognized.
  • Antemortem diagnosis is now feasible due to advancements in noninvasive imaging techniques.
  • Current treatment methods for syringomyelia show limited success in reversing clinical symptoms.

Purpose of the Study:

  • To review historical perspectives on syringomyelia, including clinical observations and experimental studies.
  • To document existing animal models for major types of syringomyelia.
  • To highlight the need for and imminent development of relevant animal models for posttraumatic syringomyelia.

Main Methods:

  • Literature review of historical clinical observations and experimental studies.

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  • Compilation and analysis of reported animal models for syringomyelia.
  • Discussion of recent advancements suggesting the imminent development of a posttraumatic syringomyelia model.

    • Main Results:

    • Historical recognition of syringomyelia dates back centuries.
    • Noninvasive imaging has enabled antemortem diagnosis.
    • Understanding the pathological basis remains incomplete, impeding treatment development.

    Conclusions:

    • Effective treatment for syringomyelia is hampered by an incomplete understanding of its pathogenesis.
    • The development of relevant animal models is crucial for defining cyst formation mechanisms.
    • Experimental models will facilitate the testing of novel therapeutic interventions for syringomyelia.