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Endothelium-dependent microvascular responses to activated complement

A S Lübbe1, R N Garrison, P D Harris

  • 1Department of Medicine, R. Virchow Medical School, Freie Universität Berlin, Federal Republic of Germany.

The Journal of Surgical Research
|December 1, 1994
PubMed
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Complement activation mediates microvascular changes in skeletal muscle during sepsis. This involves both large arteriole constriction and small arteriole dilation, crucial for blood flow regulation in sepsis.

Area of Science:

  • Physiology
  • Immunology
  • Microcirculation

Background:

  • Sepsis, particularly bacteremia from Escherichia coli, causes distinct microvascular changes in skeletal muscle.
  • Host defense during bacteremia involves complement system activation.
  • Endothelial-derived relaxing factor (EDRF) plays a role in the vasodilation of small arterioles during sepsis.

Purpose of the Study:

  • To investigate if alternative complement cascade activation mediates microvascular responses observed during bacteremia.
  • To explore the role of EDRF in skeletal muscle small arteriole vasodilation during complement activation.

Main Methods:

  • Administered zymosan intravenously to Sprague-Dawley rats to activate the complement system.
  • Observed microvascular responses in cremaster muscle arterioles.

Related Experiment Videos

  • Utilized hydroquinone to block endothelial-derived relaxing factor (EDRF) action.

    • Main Results:

    • Complement activation mimicked the microvascular responses seen in bacteremia: large arteriole constriction and small arteriole dilation.
    • EDRF blockade abolished both small arteriole dilation and large arteriole constriction induced by complement activation.
    • Cardiac output remained normal or elevated during complement activation.

    Conclusions:

    • Components of the complement system likely mediate skeletal muscle microcirculatory responses during Escherichia coli sepsis.
    • Endothelial-derived relaxing factor (EDRF) is essential for the vasodilation of small arterioles and plays a role in large arteriole constriction during complement activation in skeletal muscle.