Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular interactions in the metastatic process

G L Nicolson, C R Birdwell, K W Brunson

    Progress in Clinical and Biological Research
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bacterial toxins and heart function: heat-labile <i>Escherichia coli</i> enterotoxin B promotes changes in cardiac function with possible relevance for sudden cardiac death.

    Biophysical reviews·2023
    Same author

    Lead poisoning: acute exposure of the heart to lead ions promotes changes in cardiac function and Cav1.2 ion channels.

    Biophysical reviews·2017
    Same author

    Chemically mediated ovipositional behaviors of the european corn borer,Ostrinia nubilalis (Lepidoptera: Pyralidae).

    Journal of chemical ecology·2013
    Same author

    Difference in topology of normal and tumour cell membranes shown by different surface distributions of ferritin-conjugated concanavalin A.

    Nature: New biology·2010
    Same author

    [Different integrin-induced adhesion of highly liver metastatic and little metastatic colon carcinoma cells in an extracellular matrix].

    Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress·2003
    Same author

    Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms.

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2003
    Same journal

    DNA homology and chromosome stability: a sensitive yeast genetic system for identifying double-stranded DNA damage.

    Progress in clinical and biological research·2018
    Same journal

    Endotoxin and sepsis: molecular mechanisms of pathogenesis, host resistance, and therapy. Proceedings of the 4th Conference of the International Endotoxin Society. Nagoya, Japan, October 23-27, 1996.

    Progress in clinical and biological research·1998
    Same journal

    The pathogenic role of LBP in gram-negative sepsis and septic shock.

    Progress in clinical and biological research·1998
    Same journal

    The role of interleukin 6 in endotoxin-induced inflammatory responses.

    Progress in clinical and biological research·1998
    Same journal

    Role of nitric oxide and reactive oxygen species in endotoxin shock.

    Progress in clinical and biological research·1998
    Same journal

    Interaction of lipopolysaccharide with a mammalian lyso-phosphatidate acyltransferase (LPAAT) transfected into E. coli, and effect of lisofylline on LPAAT transfected into mammalian cells.

    Progress in clinical and biological research·1998
    See all related articles

    Tumor metastasis involves complex interactions between cancer cells and the host. Researchers used animal models to select for tumor variants, aiding the study of metastasis mechanisms.

    Area of Science:

    • Oncology
    • Cell Biology
    • Cancer Research

    Background:

    • Tumor metastasis is a complex, multi-step process influenced by both tumor and host factors.
    • The interaction between circulating tumor cells and host endothelial cells is crucial for metastasis.
    • Understanding these interactions is key to developing anti-metastatic therapies.

    Purpose of the Study:

    • To investigate the mechanisms underlying tumor cell arrest and organ-specific metastasis.
    • To identify cell surface structures and enzymes involved in the metastatic cascade.
    • To utilize experimental animal models for studying metastasis dynamics.

    Main Methods:

    • Employing experimental animal models to study tumor metastasis.
    • Implementing in vivo selection to isolate tumor cell variants with altered metastatic potential.

    Related Experiment Videos

  • Analyzing the characteristics of selected tumor variants to understand metastatic processes.

    • Main Results:

    • Demonstrated that tumor cell variants can be selected for specific organ tropism.
    • Showcased the ability to manipulate the frequency and location of metastatic foci.
    • Identified potential cell surface molecules and enzymes implicated in metastasis.

    Conclusions:

    • Tumor cell properties significantly influence metastatic site selection and survival.
    • In vivo selection is a viable strategy to uncover molecular players in metastasis.
    • Further research into identified cell surface structures and enzymes could yield therapeutic targets.