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Liver sinusoidal washout cells transferred to allogeneic recipients reveal tolerogenic properties
W L Olszewski1, M Jasklowska-Englisz, B Lukomska
1Medical Research Center, Polish Academy of Sciences, Warsaw.
Liver sinusoidal washout cells, containing a large fraction of LGL cytotoxic to tumor cell lines in vitro, are less responsive to mitogens and suppress the responsiveness of autologous and third-party PBM to mitogens and autologous mixed lymphocyte culture, compared with autologous portal vein or PBM. They are less immunogenic after IV administration into allogeneic recipients, which can be observed in an in vivo allogeneic lymphocyte cytotoxicity test. Immunization of allogeneic recipients with liver sinusoidal washout cells slightly prolongs heart allograft survival time.
Liver sinusoidal washout cells, containing a large fraction of LGL cytotoxic to tumor cell lines in vitro, are less responsive to mitogens and suppress the responsiveness of autologous and third-party PBM to mitogens and autologous mixed lymphocyte culture, compared with autologous portal vein or PBM. They are less immunogenic after IV administration into allogeneic recipients, which can be observed in an in vivo allogeneic lymphocyte cytotoxicity test. Immunization of allogeneic recipients with liver sinusoidal washout cells slightly prolongs heart allograft survival time.