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[Inherited thrombophilia]
1Samodzielnej Pracowni Krzepniecia Krwi i Hemostazy, Instytutu Hematologii i Transfuzjologii, Warszawie.
The prevalence of inherited thrombophilia in the general population (1 in 2,500) is higher than that of hemophilia and related bleeding disorders. Well established causes of thrombophilia include deficiencies of natural coagulation inhibitors: antithrombin III, protein C and protein S. It is likely that other inherited disorders, such as deficiency of the second cofactor for activated protein C, deficiency of heparin cofactor II, hypo- and dysplasminogenemias, dysfibrinogenemias and homocysteinemia, may predispose to thrombosis. This review discusses clinical and laboratory aspects of these disorders and summarizes the management of individuals with inherited thrombophilia.
The prevalence of inherited thrombophilia in the general population (1 in 2,500) is higher than that of hemophilia and related bleeding disorders. Well established causes of thrombophilia include deficiencies of natural coagulation inhibitors: antithrombin III, protein C and protein S. It is likely that other inherited disorders, such as deficiency of the second cofactor for activated protein C, deficiency of heparin cofactor II, hypo- and dysplasminogenemias, dysfibrinogenemias and homocysteinemia, may predispose to thrombosis. This review discusses clinical and laboratory aspects of these disorders and summarizes the management of individuals with inherited thrombophilia.