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Related Experiment Videos

Psyllium hypersensitivity

G L Freeman1

  • 1Department of Internal Medicine, CIGNA Healthcare of Arizona, Phoenix.

Annals of Allergy
|December 1, 1994
PubMed
Summary
This summary is machine-generated.

Psyllium hypersensitivity can cause allergic reactions, including skin rashes and respiratory symptoms, after prolonged use. Allergens are protein-based, found in the psyllium seed, not the husk.

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Area of Science:

  • Allergy and Immunology
  • Gastroenterology
  • Dermatology

Background:

  • Psyllium laxatives are widely used by millions daily.
  • Dietary supplements containing psyllium are also used for cholesterol management and colon cancer prevention.

Observation:

  • A 40-year-old woman developed a widespread pruritic rash, chest tightness, and lip swelling after two years of regular psyllium laxative use.
  • Symptoms resolved upon psyllium discontinuation and recurred upon re-challenge.

Findings:

  • The patient exhibited elevated total serum IgE and a positive psyllium-specific IgE (Plantago ovata antigen).
  • Allergens are proteinaceous, originating from the psyllium seed's inner endosperm and embryo, not the husk.

Implications:

Related Experiment Videos

  • This case highlights psyllium hypersensitivity as a potential adverse effect of chronic ingestion.
  • Accurate diagnosis requires considering psyllium allergy in patients with unexplained allergic symptoms and a history of psyllium use.