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[Glycated hemoglobin: assay methods and problems of standardization]
P Gillery1, C Guillemin, M Delpech
1Laboratoire central de biochimie, CHR de Reims, hôpital Robert-Debré, Reims.
Annales De Biologie Clinique
|January 1, 1994
Summary
Assaying glycated hemoglobin (HbA1c) involves various methods with performance challenges. Standardization is crucial for accurate diabetic control monitoring, requiring strict method performance control.
Area of Science:
- Clinical Chemistry
- Diabetology
Background:
- Glycated hemoglobin assays are vital for diabetes management.
- Current methods for measuring glycated hemoglobin exhibit performance variability and control difficulties.
Purpose of the Study:
- To review common glycated hemoglobin assay methods.
- To discuss standardization challenges and the significance of HbA1c for diabetic control.
Main Methods:
- Review of techniques measuring specifically glycated A1c hemoglobin (HbA1c) and total glycated hemoglobin.
- Discussion of standardization issues stemming from the lack of reference materials and methods.
Main Results:
- Glycated hemoglobin assay performance varies significantly between methods.
- HbA1c is identified as the most critical parameter for monitoring diabetes control.
Conclusions:
- Standardization of glycated hemoglobin assays is achievable.
- Strict control over assay method performance is essential for reliable HbA1c calibration and diabetes monitoring.