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[Plasma fractionation. Progress, problems and perspectives]

T Burnouf1

  • 1Service de Fractionnement du Plasma, Centre Régional de Transfusion Sanguine, Lille.

Annales Pharmaceutiques Francaises
|January 1, 1994
PubMed
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Plasma fractionation advancements have significantly improved the viral safety and purity of plasma-derived therapies. New methods enhance protection against viruses like HIV and hepatitis, ensuring safer treatments for various medical conditions.

Area of Science:

  • Biochemistry
  • Biotechnology
  • Medical Science

Context:

  • Plasma fractionation has undergone significant technological evolution.
  • Introduction of novel viral inactivation techniques like solvent-detergent and pasteurization.
  • Development of chromatographic methods (ion exchange, immunopurification) for enhanced product purity.

Purpose:

  • To improve the viral safety and purity of plasma-derived products.
  • To ensure inactivation of major plasma-borne viruses, including HIV, hepatitis B, and C.
  • To develop highly purified protein concentrates for targeted hemotherapy.

Summary:

  • New generations of Factor VIII and IX concentrates exhibit 10,000-20,000-fold purification.
  • Standardized concentrates for von Willebrand factor, factor XI, protein C, and alpha 1-antitrypsin are now available.

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  • Good Manufacturing Practices ensure consistent product quality through controlled, validated processes.

    • Impact:

    • Plasma-derived therapies now offer significantly higher safety levels regarding purity and viral risks.
    • Enables selective hemotherapy for specific congenital or acquired deficiencies.
    • Ongoing research aims to address emerging threats and potential immunogenicity, with viral filtration on the horizon.