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Effect of endotoxin on the peritoneal mast cells in mice
Acta Biologica Academiae Scientiarum Hungaricae
|January 1, 1976
Abstract:
Endotoxin administered intraperitoneally has been found to decrease the absolute and relative number of the peritoneal mast cells in mice. The number of peritoneal mast cells showed a dose-dependent biphasic response to endotoxin. Maximal and more consistent decrease in the peritoneal mast cell count was observed at about 24 h and lasted for at least 4 days. Mast cell damage also occurred. The possible mechanism of this phenomenon is discussed.