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Related Experiment Videos

Chaotic hemodynamic during oscillated blood flow

T Yambe1, S Nitta, T Sonobe

  • 1Department of Medical Engineering and Cardiology, School of Medicine, Tohoku University, Sendai, Japan.

Artificial Organs
|September 1, 1994
PubMed
Summary

Vibrating flow pumps (VFPs) create oscillated blood flow, altering circulatory dynamics. Nonlinear analysis reveals this artificial circulation may exhibit a lower-dimensional chaotic state, impacting regulatory system stability.

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Area of Science:

  • Cardiovascular physiology
  • Biomedical engineering
  • Nonlinear dynamics

Background:

  • Artificial heart systems require pumps that mimic natural circulation.
  • Vibrating flow pumps (VFPs) generate oscillated blood flow (10-50 Hz/min), differing from natural heart patterns.
  • Understanding the impact of VFP-generated flow on circulatory regulation is crucial.

Purpose of the Study:

  • To analyze the hemodynamics of high-frequency oscillated blood flow generated by VFPs.
  • To investigate the effect of VFP-induced blood flow on the circulatory regulatory system.
  • To characterize the dynamic system of circulation under VFP support using nonlinear mathematical techniques.

Main Methods:

  • Implantation of VFPs in adult goats, creating a complete left heart circulation model.

Related Experiment Videos

  • Application of nonlinear mathematical techniques to analyze arterial blood pressure waveforms.
  • Utilizing phase space reconstruction and Lyapunov numerical methods to assess system dynamics.

    • Main Results:

    • Natural circulation exhibited a high-dimensional complex attractor, indicative of deterministic chaos.
    • VFP-supported circulation displayed a limit-cycle attractor with a forbidden zone, suggesting a lower-dimensional dynamic system.
    • A positive Lyapunov exponent during VFP flow indicated lower-dimensional chaotic dynamics.

    Conclusions:

    • Circulatory regulation under oscillated blood flow may represent a lower-dimensional homeochaotic state.
    • Hemodynamic parameters require careful management in VFP-supported circulation, especially with external stimuli.
    • Nonlinear analysis provides insights into the complex dynamics of artificial circulatory systems.