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Related Experiment Videos

A miniaturized centrifugal pump for assist circulation

S Taguchi1, R Yozu, A Mori

  • 1Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.

Artificial Organs
|September 1, 1994
PubMed
Summary

The new Nikkiso HMS-15 miniaturized centrifugal pump demonstrates comparable hemolysis to larger devices. Its compact design offers effective cardiac assist and cardiopulmonary bypass, challenging assumptions about pump size.

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Area of Science:

  • Biomedical Engineering
  • Medical Devices
  • Cardiovascular Technology

Background:

  • Traditional centrifugal pumps often require larger diameters for optimal performance.
  • Miniaturization in medical devices is crucial for improved patient outcomes and surgical procedures.
  • Assessing hemocompatibility and blood trauma is essential for cardiac assist devices.

Purpose of the Study:

  • To introduce and evaluate the novel Nikkiso HMS-15 miniaturized centrifugal pump.
  • To compare the hemocompatibility of the HMS-15 with larger, established centrifugal pumps.
  • To assess the clinical efficacy and safety of the HMS-15 in cardiac assist and cardiopulmonary bypass applications.

Main Methods:

  • Development of a novel miniaturized centrifugal pump (Nikkiso HMS-15) with a 50 mm impeller diameter and 25 ml priming volume.

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  • Hemolysis testing to compare the HMS-15 with larger centrifugal pumps, using the index of hemolysis.
  • Clinical application assessment during 48-hour cardiac assist and cardiopulmonary bypass procedures.

    • Main Results:

    • The Nikkiso HMS-15 exhibited hemolysis comparable to pumps twice its size (index of hemolysis, 0.005).
    • No thrombus formation was observed during a 48-hour cardiac assist application, even with low heparin dosage.
    • Favorable blood trauma and high controllability were noted during cardiopulmonary bypass for open heart surgery.

    Conclusions:

    • The miniaturized Nikkiso HMS-15 centrifugal pump is a reliable and effective device for cardiac assist and cardiopulmonary bypass.
    • The study refutes the notion that larger pump diameters are always necessary for acceptable hemocompatibility.
    • The pump's compact design, controllability, and versatility make it highly suitable for clinical applications.