[Histochemical characteristics of experimental candidiasis with specific sensitization]

The authors studied histochemically the significance of specific sensitization in the pathogenesis of specific moniliasis. The activity of various enzymes of the fungus and of the cells of the inflammatory infiltrate with the subsequent quantitative assessment was determined. In visceral moniliasis tissue changes were in a definite correlation with the changes of the active agents in the cells of the fungus and in the cells of the inflammatory inflitrate. An increase in the activity of the fungus enzymes was noted at the early periods of parasitic infestation; this was later replaced by its reduction, coinciding with the reduction of the amount of the vegetative forms. Preliminary administration of the moniliasis allergen induced an increase of the sensitivity to the subsequent infection. Changes in the specifically sensitized rats developed against the background of marked vascular disturbances and coursed by the hyperergic type.