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Quantitative evaluations of male pattern baldness
Journal of Dermatological Science
|July 1, 1994
Summary
This study introduces new quantitative methods to assess hair growth, revealing a natural decrease in hair thickness and the anagen ratio over three years in Japanese adults. These findings aid in evaluating hair loss progression and treatments.
Area of Science:
- Dermatology
- Trichology
- Biometry
Background:
- Existing hair growth evaluation methods lack unbiased, double-blind study capabilities.
- Accurate assessment of hair growth agents and conditions like male pattern baldness is challenging.
Purpose of the Study:
- To introduce novel quantitative methods for evaluating hair growth.
- To assess hair diameter and anagen ratio changes over time.
- To validate these methods for unbiased, double-blind studies on hair growth agents and male pattern baldness.
Main Methods:
- Quantitative measurement of anagen ratio and hair diameters.
- Longitudinal study over 3 years involving 56 Japanese subjects (aged 23-56).
- Subject grouping based on anagen ratio to analyze hair diameter distributions.
Main Results:
- Average anagen ratio decreased by 3.8% over 3 years.
- Average hair diameter showed a statistically significant decrease of 3.4 microns annually.
- Higher anagen ratio correlated with thicker hair; lower ratio with thinner hair.
- A decrease in thicker hairs and a shift towards thinner hair diameters were observed over time.
Conclusions:
- The developed quantitative methods provide an unbiased, objective approach for hair growth evaluation.
- These methods are effective for tracking male pattern baldness progression.
- The study demonstrates the utility of these methods in double-blind efficacy studies for hair growth agents.