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Nefopam hydrochloride: new analgesic agent

A Cohen, C M Hernandez

    The Journal of International Medical Research
    |January 1, 1976
    PubMed
    Summary

    Nefopam hydrochloride (30 mg and 60 mg) demonstrated superior pain relief for muscle disorders compared to low-dose aspirin. High-dose aspirin (600 mg) and low-dose nefopam (30 mg) were also effective pain relievers.

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    Area of Science:

    • Pharmacology
    • Pain Management
    • Clinical Trials

    Background:

    • Muscle disorders often cause significant pain, necessitating effective analgesic treatments.
    • Nefopam hydrochloride and aspirin are commonly used analgesics with different mechanisms of action.
    • Comparative efficacy data for these drugs in muscle pain is crucial for clinical decision-making.

    Purpose of the Study:

    • To compare the analgesic efficacy and safety of two doses of nefopam hydrochloride against two doses of aspirin and placebo in patients with muscle pain.
    • To evaluate the time-course of analgesic action for each treatment group.

    Main Methods:

    • A randomized, placebo-controlled study involving 125 male patients with muscle disorder pain.
    • Single-dose administration of nefopam (30 mg, 60 mg), aspirin (300 mg, 600 mg), or placebo.
    • Pain intensity and side effects were monitored hourly for four hours post-administration.

    Main Results:

    • Aspirin 300 mg showed no statistically significant analgesia compared to placebo.
    • Nefopam 60 mg provided significant pain relief compared to placebo at 1 and 3 hours.
    • Aspirin 600 mg and nefopam 30 mg demonstrated significant analgesic effects across multiple time points compared to placebo.

    Conclusions:

    • Nefopam hydrochloride, particularly at 60 mg, offers significant pain relief for muscle disorders.
    • Higher doses of aspirin (600 mg) and lower doses of nefopam (30 mg) also show efficacy.
    • Nefopam appears to be a viable and effective option for managing pain associated with muscle disorders.

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