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Primary splenic lymphoma in a horse
T Tanimoto1, S Yamasaki, Y Ohtsuki
1Chuo Meat Inspection Laboratory, Kochi Prefecture, Japan.
The Journal of Veterinary Medical Science
|August 1, 1994
Summary
A large splenic mass in a stallion was identified as a B-cell lymphoma. Despite high cell proliferation, the tumor showed no signs of metastasis, posing an unusual diagnostic challenge.
Area of Science:
- Veterinary Pathology
- Equine Neoplasia
- B-Cell Lymphoma
Background:
- Primary splenic tumors are rare in horses.
- Understanding equine lymphoma subtypes is crucial for diagnosis and treatment.
Observation:
- A 4-year-old Thoroughbred stallion presented with a large, well-demarcated solitary splenic mass.
- The mass exhibited hemorrhagic and necrotic areas.
- Histological examination revealed diffuse large non-cleaved cell lymphoma with a high mitotic index and a 'starry sky' pattern.
Findings:
- Lymphoma cells were positive for acid phosphatase, alpha naphthyl butyrate esterase, and proliferating cell nuclear antigen.
- Intracytoplasmic IgM was occasionally detected, indicating B-cell origin.
- Ultrastructural analysis showed features of active protein synthesis in the lymphoma cells.
Implications:
- This case represents a primary splenic lymphoma of B-cell origin in a horse.
- The lack of metastasis or invasive growth, despite high proliferative activity, remains unexplained.
- Further research is needed to understand the factors influencing the behavior of equine splenic lymphomas.