Jove
Visualize
Contact Us

Related Experiment Videos

Changing indications in liver transplantation

M Webberley1, J Neuberger

  • 1Queen Elizabeth Hospital, Birmingham, UK.

Bailliere'S Clinical Gastroenterology
|September 1, 1994
PubMed
Summary

Orthotopic liver transplantation now offers over 90% survival, but selecting optimal timing and recipients for liver replacement remains challenging. Research explores alternatives and improving indications while minimizing immunosuppression side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect on consent rates for deceased organ donation in Wales after the introduction of an opt-out system.

Anaesthesia·2020
Same author

Editorial: covert hepatic encephalopathy-silent but serious.

Alimentary pharmacology & therapeutics·2018
Same author

Confirmation of specificity of reactivity in a solid phase ELISA for the detection of hepatitis E viral antigen improves utility of the assay.

Journal of virological methods·2017
Same author

Primary Mental Abilities.

The Journal of general psychology·2017
Same author

Donors With Immune Thrombocytopenia: Do They Pose a Risk to Transplant Recipients?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

The inter-relationship of symptom severity and quality of life in 2055 patients with primary biliary cholangitis.

Alimentary pharmacology & therapeutics·2016
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Hepatology
  • Transplantation Medicine
  • Immunosuppression

Background:

  • Orthotopic liver transplantation (OLT) has evolved into a routine procedure with high 1-year survival rates (>90%) in elective cases.
  • Increasing experience has shifted focus towards refining OLT indications and determining optimal procedural timing.
  • Challenges persist in selecting patients with fulminant hepatic failure for timely transplantation before irreversible complications arise.

Purpose of the Study:

  • To review advancements in liver transplantation, including indications and timing.
  • To assess alternative strategies to OLT.
  • To highlight ongoing efforts in managing long-term sequelae and reducing immunosuppression.

Main Methods:

  • Review of current practices and outcomes in orthotopic liver transplantation.
  • Assessment of emerging alternative liver support and transplantation methods (heterotopic, partial OLT, xenografting).
  • Analysis of progress in patient selection for viral hepatitis and alcoholic liver disease.

Main Results:

  • High survival rates achieved in elective OLT cases.
  • Difficulties remain in timely organ allocation for fulminant hepatic failure.
  • Progress noted in indications for viral hepatitis and alcoholic liver disease.
  • Long-term immunosuppression sequelae necessitate strategies for reduction.

Conclusions:

  • Liver transplantation is a successful treatment but prevention of end-stage liver disease is paramount.
  • Ongoing research focuses on optimizing patient selection, exploring alternatives, and mitigating immunosuppression's long-term effects.
  • Further advancements are needed to improve outcomes and reduce the burden of immunosuppressive therapy in liver transplant recipients.

Related Experiment Videos