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Blood antioxidants and indices of lipid peroxidation in subjects with angina pectoris
G G Duthie1, J A Beattie, J R Arthur
1Rowett Research Institute, Aberdeen, Scotland, United Kingdom.
Insights
This study compared blood antioxidants in patients with coronary heart disease (CHD) to controls. Angina patients showed higher oxidative stress, suggesting a link, but causality remains unclear.
Area of Science:
- Cardiovascular Medicine
- Nutritional Science
- Biochemistry
Background:
- Coronary heart disease (CHD) is a leading cause of mortality worldwide.
- The antioxidant hypothesis suggests that oxidative stress contributes to CHD development.
- Understanding the role of antioxidants and oxidative stress in CHD is crucial for prevention and treatment.
Purpose of the Study:
- To investigate the antioxidant status and oxidative stress markers in patients with stable angina pectoris.
- To compare these markers with those of healthy controls.
- To evaluate the relevance of the antioxidant hypothesis in the context of CHD.
Main Methods:
- Blood samples were collected from 25 patients with stable angina pectoris and 200 matched controls.
- Plasma concentrations of antioxidants (Vitamins A, C, E), uric acid, lipids (total cholesterol, LDL, triglycerides), and markers of lipid peroxidation were measured.
- Classic CHD risk factors including body mass index, plasma cotinine, and blood pressure were also assessed.
Main Results:
- Angina patients exhibited significantly higher plasma concentrations of total cholesterol, low-density lipoproteins (LDL), and triglycerides compared to controls.
- Despite similar levels of Vitamins A, C, and E, angina subjects had lower plasma uric acid concentrations.
- Indices of lipid peroxidation were significantly elevated in patients with angina, indicating increased oxidative stress.
Conclusions:
- The findings are consistent with the antioxidant hypothesis of CHD, as evidenced by increased oxidative stress in angina patients.
- However, the study could not definitively establish whether the observed oxidative stress is a cause or a consequence of coronary heart disease.
- Further research is needed to elucidate the causal relationship between oxidative stress and CHD development.
Abstract:
We tested the antioxidant hypothesis of coronary heart disease (CHD) by comparing blood antioxidants, indices of lipid peroxidation and classic (CHD) risk factors of 25 subjects with stable angina pectoris with 200 matched controls. Angina subjects had significantly increased plasma concentrations of total cholesterol, low density lipoproteins and triglycerides although body mass index, plasma cotinine concentration and blood pressure were similar to those of the control group. Plasma concentrations of vitamin A, vitamin C and cholesterol- adjusted vitamin E did not differ between the groups although subjects with angina had significantly decreased plasma uric acid concentrations and elevated indices of lipid peroxidation. Although the results are compatible with the antioxidant hypothesis, it is unclear whether the increased oxidative stress in angina sufferers is a cause or consequence of the disease.