Pulmonary hair embolism in monkeys

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A Kast1

  • 1Boehringer Ingelheim GmbH, Germany.

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie
|August 1, 1994
PubMed

Insights

Daily injections in monkeys caused skin and hair emboli in lungs (7.6%) and injection site lesions (91%). Most lesions healed after treatment stopped, with no lasting pulmonary issues observed.

Area of Science:

  • Veterinary Pathology
  • Toxicology
  • Primate Research

Background:

  • Intravenous injections are common in preclinical studies.
  • Potential complications include embolism and local tissue reactions.

Purpose of the Study:

  • To evaluate the safety and potential adverse effects of daily intravenous injections in non-human primates.
  • To assess the incidence of pulmonary emboli and injection site reactions.

Main Methods:

  • 184 rhesus and cynomolgus monkeys received daily intravenous injections for 28 days.
  • Animals were monitored for pulmonary lesions and injection site reactions.
  • Histopathological examination was performed on relevant tissues.

Main Results:

  • Pulmonary emboli, containing skin or hair fragments, were found in 7.6% of the monkeys.
  • Injection site lesions, primarily bleeding and chronic periphlebitis, occurred in 91% of animals.
  • Skin or hair particles were rarely found around the injection veins (2.2%).

Conclusions:

  • Daily intravenous injections can lead to pulmonary embolism and local inflammatory responses in non-human primates.
  • The observed lesions showed a high degree of healing after treatment cessation.
  • These findings highlight the importance of aseptic techniques during injections in primate studies.

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