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Updated: Aug 5, 2026
Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
[Pulmonary aspergillomas. Analysis of 31 patients]
J Garrós Garay1, E Ruiz de Gordejuela, F Vara Quadrado
1Hospital de Santa Marina, Bilbao, Vizcaya.
Abstract:
Thirty-one patients with pulmonary aspergilloma were studied retrospectively, leading to the following main findings: 1) Men are most often affected (90% of cases). 2) Diagnosis occurs significantly more often when the patient is between 50 to 60 years of age. 3) Aspergilloma originates most often in residual pulmonary tuberculosis (74% of cases). 4) The incidence of hemoptysis was high (87% of patients). Traditional tomography afforded images that were diagnostically useful in 77.4% of the cases, whereas simple X-rays were useful in only 38.7%. 6) In 94% aspergilloma occurred in the upper lobes. 7) Aspergillus was found in respiratory secretions in 55%. 8) Serum samples were positive for Aspergillus precipitins in 94.4%. 9) Forty-eight percent did not meet criteria for surgical intervention. 10) Noteworthy features of the course of the disease were that spontaneous lysis occurred in 13.6% and that hemoptysis led to death in 9%.
Insights
Pulmonary aspergilloma predominantly affects men aged 50-60, often stemming from tuberculosis. High rates of hemoptysis and upper lobe involvement were observed, with Aspergillus confirmed in secretions and serum.
Area of Science:
- Pulmonology
- Infectious Diseases
- Radiology
Background:
- Pulmonary aspergilloma is a serious fungal infection.
- Understanding its epidemiology and clinical presentation is crucial for diagnosis and management.
Purpose of the Study:
- To retrospectively analyze the clinical characteristics, diagnostic methods, and outcomes of pulmonary aspergilloma.
- To identify key features associated with this condition.
Main Methods:
- Retrospective study of 31 patients diagnosed with pulmonary aspergilloma.
- Review of patient demographics, medical history, diagnostic imaging (tomography, X-rays), laboratory results (Aspergillus detection in secretions and serum), and treatment outcomes.
Main Results:
- The study identified a male predominance (90%) and a peak incidence in the 50-60 age group.
- Pulmonary tuberculosis was the most common predisposing factor (74%), with high rates of hemoptysis (87%).
- Aspergilloma predominantly occurred in upper lobes (94%), with high detection rates in respiratory secretions (55%) and serum precipitins (94.4%). Traditional tomography was more effective than simple X-rays for diagnosis.
Conclusions:
- Pulmonary aspergilloma is strongly associated with prior tuberculosis, particularly in middle-aged men, and frequently presents with hemoptysis.
- Diagnostic confirmation relies on imaging and serological tests, with tomography showing superior utility.
- A significant proportion of patients are not surgical candidates, and while spontaneous lysis can occur, hemoptysis remains a risk for mortality.
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