Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epilepsy brain surgery: a Pittsburgh perspective

R M Dasheiff1, C W Ryan, J R Lave

  • 1University of Pittsburgh Epilepsy Center, University of Pittsburgh School of Medicine, PA 15261.

Seizure
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DART (NCI/SWOG S1609): comprehensive final results from dual checkpoint inhibition with CTLA-4 and PD-1 blockade in rare cancers.

Annals of oncology : official journal of the European Society for Medical Oncology·2026
Same author

A first-in-human, Phase 1/2a, open-label study of SQ3370, a first-in-class doxorubicin-based click chemistry therapeutic, in patients with advanced solid tumors.

medRxiv : the preprint server for health sciences·2025
Same author

RING1 missense variants reveal sensitivity of DNA damage repair to H2A monoubiquitination dosage during neurogenesis.

Nature communications·2024
Same author

Public health response to an imported case of canine melioidosis.

Zoonoses and public health·2018
Same author

Employment patterns among parents of children with insulin-dependent diabetes mellitus (IDDM).

Work (Reading, Mass.)·2014
Same author

Acute care practices relevant to quality end-of-life care: a survey of Pennsylvania hospitals.

Quality & safety in health care·2010
Same journal

Expanding the genotypic landscape of the neuronal ceroid lipofuscinoses: clinical and molecular findings from a tertiary-care center in Argentina.

Seizure·2026
Same journal

Effect of chronic migraine treatment on functional seizure frequency: An exploratory study.

Seizure·2026
Same journal

Development of a standard for epilepsy semiology and semiological description dataset: a modified Delphi study.

Seizure·2026
Same journal

UNC13A-related neurodevelopmental disorders in children: epilepsy phenotypes and antiseizure medication response.

Seizure·2026
Same journal

Switching from oxcarbazepine to eslicarbazepine in patients with focal epilepsy: A systematic review and single-arm meta-analysis.

Seizure·2026
Same journal

Efficacy, tolerability, and EEG lateralization-based predictors of neuropsychiatric adverse events in pediatric SeLECTS treated with perampanel monotherapy.

Seizure·2026
See all related articles

Epilepsy brain surgery in the US has limited evidence for cost-effectiveness and quality of life improvements. Future research is hindered by patient recruitment and funding challenges, preventing robust clinical trials.

Area of Science:

  • Neurosurgery
  • Epileptology
  • Health Economics

Background:

  • Epilepsy brain surgery has a historical context in the United States.
  • Current practices and outcomes require critical evaluation.

Purpose of the Study:

  • To review the efficacy and quality of life impact of epilepsy brain surgery.
  • To assess the cost-effectiveness of this treatment modality.
  • To identify barriers to essential clinical research.

Main Methods:

  • Literature review and critical analysis of existing data.
  • Examination of historical trends and current status.
  • Discussion of challenges in prospective research.

Main Results:

Related Experiment Videos

  • Limited empirical evidence supports epilepsy brain surgery as cost-effective.
  • Insufficient data exists on the impact on quality of life.
  • Prospective randomized clinical trials are lacking.

    • Conclusions:

    • Epilepsy brain surgery efficacy and cost-effectiveness remain inadequately supported by evidence.
    • Significant obstacles, including patient recruitment and funding, impede necessary research.
    • Further investigation is required to establish definitive treatment guidelines.