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Cryptococcus neoformans infection can elicit protective antibodies in mice
J Mukherjee1, M D Scharff, A Casadevall
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Canadian Journal of Microbiology
|October 1, 1994
Abstract:
An IgG1 monoclonal antibody generated from a mouse infected with Cryptococcus neoformans modified the course of intravenous cryptococcal infection in A/J mice by prolonging survival and reducing lung fungal burden, brain mass, and serum polysaccharide levels. The results demonstrate that C. neoformans infection can elicit useful antibodies.