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Related Experiment Videos

Bone cancers

H D Dorfman1, B Czerniak

  • 1Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, New York, New York.

Cancer
|January 1, 1995
PubMed
Summary

This study analyzed bone sarcoma data from 1973-1987, revealing osteosarcoma and chondrosarcoma as most common. Findings aid in diagnosing these rare but lethal bone cancers.

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Area of Science:

  • Oncology
  • Epidemiology
  • Orthopedic Surgery

Background:

  • Frequency distribution of primary bone sarcomas aids diagnosis post-radiograph identification.
  • Age and skeletal site are crucial for narrowing histologic categories of bone neoplasms before biopsy.

Purpose of the Study:

  • To analyze incidence and survival rates of primary bone sarcomas using SEER data.
  • To provide information for improved diagnosis of bone cancers.

Main Methods:

  • Analysis of 2627 histologically confirmed primary malignant bone tumors from the SEER program (1973-1987).
  • Data stratified by age, sex, race, and anatomical site.

Main Results:

  • Osteosarcoma (35.1%) was the most frequent, followed by chondrosarcoma (25.8%) and Ewing's sarcoma (16.0%).
  • In individuals under 20, osteosarcoma and Ewing's sarcoma were most common; over 50, chondrosarcoma predominated.
  • Five-year relative survival rates varied: chondrosarcoma (72.7%), chordoma (63.8%), malignant fibrous histiocytoma (42.9%), osteosarcoma (41.0%), and Ewing's sarcoma (41.2%).
  • Survival rates improved for chordoma and white female patients with Ewing's sarcoma during the study period.

Conclusions:

  • SEER data offers a valuable resource for evaluating incidence and survival of bone sarcomas.
  • Findings contribute to the diagnostic process for these uncommon, highly lethal tumors.

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