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11:13
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
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Breast cancer
1Department of Pathology and Preventive Medicine, University of Colorado, Boulder.
Cancer
|January 1, 1995
Summary
Histologic type significantly impacts breast cancer survival rates, with in situ carcinomas showing nearly 100% survival. Invasive ductal carcinoma is most common, but other types like papillary and tubular adenocarcinomas have higher survival rates.
Area of Science:
- Oncology
- Epidemiology
- Cancer Research
Background:
- Breast cancer is the leading cancer and second-highest cause of cancer death in US women.
- Lung cancer causes more deaths annually than breast cancer.
Purpose of the Study:
- To analyze the relative frequencies, incidence rates, and survival rates of various breast carcinoma histologic types.
- To examine differences in breast cancer characteristics based on histologic classification.
Main Methods:
- Analysis of 158,621 invasive and 10,639 in situ breast carcinoma cases from the National Cancer Institute's SEER program (1973-1987).
- Examination of relative frequencies, incidence rates, and 5-year relative survival rates by histologic type.
- Separate analysis of invasive breast carcinomas, in situ carcinomas, and sarcomas.
Main Results:
- Infiltrating duct carcinoma (67.9%) had a 79% 5-year survival rate.
- Lobular carcinoma (6.3%) had an 84% survival rate; medullary carcinoma (2.8%) had an 82% survival rate.
- Carcinoma in situ demonstrated approximately 100% 5-year relative survival across all subtypes.
Conclusions:
- Histologic type is a significant factor influencing breast cancer frequency, presentation, and patient survival.
- The SEER program provides a robust, population-based dataset for breast cancer research in the US.
- This data is crucial for understanding incidence and survival rates across different histologic types of breast cancer.
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