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Related Experiment Videos

Hodgkin's disease

L J Medeiros1, T C Greiner

  • 1Department of Pathology, Rhode Island Hospital, Providence 02903.

Cancer
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

The incidence of nodular sclerosis Hodgkin's disease increased significantly in young adults, while other subtypes remained stable or decreased. Improved diagnostics likely contributed to a decline in elderly Hodgkin's disease cases.

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Area of Science:

  • Oncology
  • Epidemiology
  • Cancer Research

Background:

  • The Surveillance, Epidemiology, and End Results (SEER) program collected Hodgkin's disease data from 1973-1987.
  • Data represented U.S. geographic regions and aimed for national representativeness.

Purpose of the Study:

  • To analyze trends in Hodgkin's disease incidence and subtypes over three decades.
  • To identify demographic and temporal patterns in Hodgkin's disease occurrence.

Main Methods:

  • Reviewed 9,418 microscopically confirmed Hodgkin's disease cases from the SEER database.
  • Analyzed incidence rates across different age groups and time periods (1973-1977, 1978-1982, 1983-1987).

Main Results:

  • Hodgkin's disease showed a bimodal age distribution (15-34 and >55 years).

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  • Nodular sclerosis incidence rose significantly, especially in young adults and females.
  • Mixed cellularity incidence was stable, but increased in older black males; lymphocytic depletion decreased, likely due to diagnostic changes.

    • Conclusions:

    • Hodgkin's disease is heterogeneous, with nodular sclerosis and mixed cellularity as distinct entities.
    • Increasing nodular sclerosis incidence contrasts with stable mixed cellularity.
    • Decreased incidence in the elderly is attributed to improved diagnostic accuracy for Hodgkin's disease and non-Hodgkin's lymphoma (NHL).