Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

African horsesickness: pathogenesis and immunity

T G Burrage1, W W Laegreid

  • 1Molecular Pathology Unit, Plum Island Animal Disease Center, USDA/ARS, Greenport, NY 11944-0848.

Comparative Immunology, Microbiology and Infectious Diseases
|August 1, 1994
PubMed
Summary

African horsesickness (AHS) is a viral disease in horses. Virulence of the infecting orbivirus strain determines the disease form, and recovery confers immunity via antibodies targeting VP2 epitopes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

African Swine Fever Virus (Asfv) Multigene Families 360 and 530 Genes Promote Infected Macrophage Survival.

TheScientificWorldJournal·2018
Same author

Scrapie resistance in ARQ sheep.

Journal of virology·2008
Same author

Classical swine fever virus inhibits nitric oxide production in infected macrophages.

The Journal of general virology·2007
Same author

Interferon type I response in porcine reproductive and respiratory syndrome virus-infected MARC-145 cells.

Archives of virology·2004
Same author

Male-specific SRY and ZFY haplotypes in US beef cattle.

Animal genetics·2004
Same author

Estimation of the basic reproduction ratio (R0) for Shiga toxin-producing Escherichia coli O157:H7 (STEC O157) in beef calves.

Epidemiology and infection·2004

Area of Science:

  • Veterinary Virology
  • Immunology

Background:

  • African horsesickness (AHS) is a severe, non-contagious disease affecting solipeds.
  • Caused by an arthropod-borne orbivirus (family Reoviridae).
  • Manifests in horses as pulmonary, cardiac, or fever syndromes.

Purpose of the Study:

  • To investigate the determinants of AHS clinical presentation.
  • To explore the nature of immunity following AHS recovery.
  • To discuss the implications for AHS vaccination.

Main Methods:

  • Analysis of clinicopathologic syndromes in horses.
  • Assessment of humoral immunity post-infection.
  • Identification of target epitopes for protective antibodies.

Main Results:

Related Experiment Videos

  • The virulence of the infecting orbivirus inoculum is the primary determinant of disease form in naive horses.
  • Recovered horses develop solid homologous immunity.
  • Protective antibodies are directed against neutralizing epitopes on AHS virus VP2.

Conclusions:

  • Virus virulence dictates AHS clinical presentation.
  • Humoral immunity, specifically antibodies to VP2, is crucial for protection.
  • Understanding these factors is key for developing effective AHS vaccines.