[The effects of the cyclopentyl ethinyl estriol on the cardiovascular function of postmenopausal women]

The cardiovascular function of postmenopausal women before and after oral supplement of cyclopentyl ethinyl estriol (CEE3) were evaluated with 3-dimensional ultrasound and Doppler technique. The results are as follows: there were no changes of HR, SBP, DBP, MBP and E2 in postmenopausal women before and after the oral supplement of CEE3. Ves and SVR were obviously reduced (P < 0.001). SV, CO, EF, Vmax V and A were obviously increased (P < 0.001). There were no changes in Ved, E and E/A. The results showed that CEE3 could reinforce the cardiac function and increase cardiac output and also reduce the resistance in peripheral blood vessels in postmenopausal women. It is assumed that the cardioprotective effect of hormone replacement therapy in postmenopausal women may be due not only to changes in lipid profile but also to direct effects of estrogens on central and peripheral hemodynamic parameters.