Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiological changes induced by pre-adaptation to high altitude

G Savourey1, N Garcia, Y Besnard

  • 1Unité de Thermophysiologie, Centre de Recherches du Service de Santé des Armées, La Tronche, France.

European Journal of Applied Physiology and Occupational Physiology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Translated article] Induced osteogenesis by chitosan (3-glycidoxypropyl)trimethoxysilane and silica-based biomaterial in rabbits.

Revista espanola de cirugia ortopedica y traumatologia·2026
Same author

Duration of androgen deprivation therapy with salvage radiotherapy in patients with prostate cancer and biochemical recurrence after surgery: Initial recruitment data in the phase III URONCOR 06-24 trial.

Actas urologicas espanolas·2025
Same author

Induced osteogenesis by chitosan (3-glycidoxypropyl)trimethoxysilane and silica based biomaterial in rabbits.

Revista espanola de cirugia ortopedica y traumatologia·2025
Same author

Gel nail polish does not have a negative impact on the nail bacterial burden nor on the quality of hand hygiene with an alcohol-based hand rub.

The Journal of hospital infection·2024
Same author

Pancreatic re-implantation following trauma with main duct disruption: Is resection always mandatory?

Journal of visceral surgery·2021
Same author

A real-life overview of a hematopoietic cell transplant program throughout a four-year period, including prospective registry, exclusion causes and final donor selection.

Bone marrow transplantation·2021

Pre-adapting to high altitude improves physiological responses to hypoxia, enhancing ventilation and oxygen saturation. This study shows benefits of acclimatization and acclimation for high-altitude expeditions.

Area of Science:

  • Physiology
  • Altitude Medicine
  • Exercise Physiology

Background:

  • Understanding physiological adaptations to high altitude is crucial for preventing altitude sickness and optimizing performance.
  • Pre-adaptation strategies may enhance the body's response to severe hypoxic conditions encountered during expeditions.

Purpose of the Study:

  • To investigate the physiological effects of pre-adaptation, including acclimatization and intermittent acclimation, on ventilatory and cardiac responses to hypoxia.
  • To assess changes in hematological parameters and key biomarkers like erythropoietin (EPO) and 2,3-diphosphoglycerate (2,3-DPG) following high-altitude exposure.

Main Methods:

  • Seven subjects underwent acclimatization at 4350 m and intermittent acclimation in a hypobaric chamber (5000–8500 m).
  • Physiological tests (ventilatory, cardiac) were performed at rest and during exercise in normoxia and hypoxia (4500 m).

Related Experiment Videos

  • Blood samples were analyzed for hemoglobin, erythrocytes, reticulocytes, packed cell volume, 2,3-DPG, and EPO at various stages.

    • Main Results:

    • Increased tidal volume and improved arterial oxygen saturation were observed in hypoxia after acclimation.
    • Systolic blood pressure increased during exercise in hypoxia post-acclimation.
    • Significant increases in reticulocytes, erythropoietin (EPO), and 2,3-diphosphoglycerate (2,3-DPG) were noted after the acclimation period.

    Conclusions:

    • Pre-adaptation, particularly intermittent acclimation, significantly enhances ventilatory and oxygenation responses to hypoxia.
    • The observed hematological and biochemical changes suggest improved oxygen transport and utilization capabilities at high altitudes.
    • These findings support the efficacy of pre-adaptation protocols for individuals undertaking high-altitude expeditions.