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Updated: Aug 10, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Intraepidermal squamous carcinoma (Bowen's disease) of the nipple
V S Venkataseshan1, D C Budd, D Un Kim
1Department of Pathology, Barnert Hospital, Paterson, NJ 07514.
Abstract:
A case of Bowen's disease of the nipple clinically resembling Paget's disease is reported. This lesion was differentiated from other pagetoid lesions by negative histochemical stains for mucin and melanin, positive immunohistochemical preparation for high-molecular weight cytokeratin 66 kd (904) using adequate controls, and electron microscopic findings of squamous cell features. The therapeutic implications of such a pagetoid nipple lesion in the absence of an underlying breast carcinoma are discussed.
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