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Cutaneous involvement in chronic myelomonocytic leukemia
D M O'Connell1, W A Fagan, S M Skinner
1Department of Dermatology, University of Texas Health Science Center, San Antonio 78284-7876.
International Journal of Dermatology
|September 1, 1994
Summary
Chronic myelomonocytic leukemia (CMML) can present with skin issues. This case shows nonspecific skin changes progressing to specific leukemic lesions as CMML develops.
Area of Science:
- Hematology
- Dermatology
- Oncology
Background:
- Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell malignancy.
- Cutaneous manifestations are common in CMML but direct skin infiltration is rare.
Observation:
- This case study details a patient's progression toward CMML.
- The patient exhibited evolving skin lesions alongside hematologic and bone marrow changes.
Findings:
- Nonspecific skin involvement preceded the development of specific leukemic lesions (leukemia cutis).
- Leukemic skin manifestations paralleled the progression of systemic and hematologic disease.
Implications:
- CMML can manifest with leukemia cutis, indicating direct skin involvement.
- Nonspecific skin changes may signal the preleukemic phase of CMML, warranting further investigation.