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Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures
C Takahashi1, A Numata, E Matsumura
1Osaka University of Pharmaceutical Sciences, Japan.
The Journal of Antibiotics
|November 1, 1994
Abstract:
Leptosins I and J, belonging to a series of epipolythiodioxopiperazines, have been isolated from the mycelium of a strain of Leptosphaeria sp. OUPS-4 attached to the marine alga Sargasssum tortile. Their relative stereostructures have been elucidated by chemical and spectral evidence. These compounds exhibited significant cytotoxic activity against cultured P388 cells.