Related Experiment Videos
[Multidrug resistance (MDR)]
1Dept. of Biochemistry, Kyushu University School of Medicine.
Abstract:
Multiple drug resistance (MDR) is a major problem of current chemotherapy. Establishment of multiple drug resistant cell lines in culture and isolation of P-glycoprotein-coding MDR genes have promoted understanding of the molecular mechanisms underlying drug resistance in tumors. Another gene, MRP, has been recently isolated from a multiple drug resistant cell line which did not express P-glycoprotein. Both genes have DNA sequence homology for each other and have been identified as members of ATP binding cassette (ABC) transporter superfamily. This review refers to recent progress in MDR and MRP study, and focuses on involvement of these two drug-resistance-related genes in acquiring drug resistance and their physiological functions.
Insights
Multiple drug resistance (MDR) is a significant challenge in chemotherapy. This review explores the roles of P-glycoprotein and the multidrug resistance-associated protein (MRP) genes in developing drug resistance and their normal physiological functions.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Context:
- Multiple drug resistance (MDR) poses a major challenge in cancer chemotherapy.
- Understanding the molecular basis of MDR is crucial for developing effective treatments.
Purpose:
- To review recent advancements in the study of MDR and the multidrug resistance-associated protein (MRP) gene.
- To focus on the involvement of P-glycoprotein and MRP in acquiring drug resistance and their physiological roles.
Summary:
- The isolation of P-glycoprotein-coding MDR genes and the MRP gene has advanced the understanding of MDR mechanisms.
- Both P-glycoprotein and MRP are identified as members of the ATP-binding cassette (ABC) transporter superfamily, sharing DNA sequence homology.
- This review discusses the contribution of these genes to drug resistance and their normal biological functions.
Impact:
- Enhanced understanding of MDR mechanisms can lead to novel therapeutic strategies.
- Identifying the physiological functions of ABC transporters may reveal new targets for drug development.
- This research is vital for overcoming chemotherapy resistance in tumors.