Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Multidrug resistance (MDR)]

M Wada1, S Hasegawa, K Kohno

  • 1Dept. of Biochemistry, Kyushu University School of Medicine.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular characterization of two Arabidopsis Ire1 homologs, endoplasmic reticulum-located transmembrane protein kinases.

Plant physiology·2001
Same author

Nuclear expression of the Y-box binding protein, YB-1, as a novel marker of disease progression in non-small cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2001
Same author

Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter.

The Journal of biological chemistry·2001
Same author

Elevated expression of vacuolar proton pump genes and cellular PH in cisplatin resistance.

International journal of cancer·2001
Same author

Medicinal foodstuffs. XXV. Hepatoprotective principle and structures of ionone glucoside, phenethyl glycoside, and flavonol oligoglycosides from young seedpods of garden peas, Pisum sativum L.

Chemical & pharmaceutical bulletin·2001
Same author

Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice.

Nature biotechnology·2001
Same journal

[A Case of Pulmonary Epithelioid Hemangioendothelioma Associated with Multiple Cancers].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Long-Term Survival in Three Cases with Pulmonary Metastases from Colorectal Cancer Given Low-Dose S-1 Under a Regimen Combining a Carbohydrate-Restricted Ketogenic Diet, Metformin, Vitamin D, Eicosapentaenoic Acid, and Other Complementary Therapies].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Preventive Effect of Saline Eye Wash for Eye Symptoms Due to High-Dose and Intermediate-Dose Cytarabine Therapy].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Examination of Factors Affecting the Efficacy of Naldemedine Tosilate Tablets for Opioid-Induced Constipation].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Recent Advances in the Treatment of HER2-Altered Solid Tumors].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[BRAF-Mutant Solid Tumor].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
See all related articles

Multiple drug resistance (MDR) is a significant challenge in chemotherapy. This review explores the roles of P-glycoprotein and the multidrug resistance-associated protein (MRP) genes in developing drug resistance and their normal physiological functions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Context:

  • Multiple drug resistance (MDR) poses a major challenge in cancer chemotherapy.
  • Understanding the molecular basis of MDR is crucial for developing effective treatments.

Purpose:

  • To review recent advancements in the study of MDR and the multidrug resistance-associated protein (MRP) gene.
  • To focus on the involvement of P-glycoprotein and MRP in acquiring drug resistance and their physiological roles.

Summary:

  • The isolation of P-glycoprotein-coding MDR genes and the MRP gene has advanced the understanding of MDR mechanisms.
  • Both P-glycoprotein and MRP are identified as members of the ATP-binding cassette (ABC) transporter superfamily, sharing DNA sequence homology.
  • This review discusses the contribution of these genes to drug resistance and their normal biological functions.

Related Experiment Videos

Impact:

  • Enhanced understanding of MDR mechanisms can lead to novel therapeutic strategies.
  • Identifying the physiological functions of ABC transporters may reveal new targets for drug development.
  • This research is vital for overcoming chemotherapy resistance in tumors.