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Scleroderma and augmentation mammoplasty--a causal relationship?

H J Englert¹, P Brooks

¹Rheumatology Unit, Royal North Shore Hospital, Sydney, NSW.

Australian and New Zealand Journal of Medicine

|February 1, 1994

Summary

This study found no link between silicone breast implants and scleroderma. Researchers compared rates of augmentation mammoplasty in scleroderma patients and controls, finding no significant difference.

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Area of Science:

Rheumatology
Plastic Surgery
Epidemiology

Background:

Previous studies suggested a link between silicone and autoimmune diseases like scleroderma, but lacked rigorous methodology.
This case-control study addresses these limitations by examining augmentation mammoplasty and scleroderma.
Potential confounders and appropriate controls were considered.

Purpose of the Study:

To compare augmentation mammoplasty frequency and timing in scleroderma cases versus controls.
To assess exposure to non-augmentation mammoplasty silicone.
To determine rates of mastectomy and breast lumpectomy in cases and controls.

Main Methods:

A case-control study design was employed, interviewing scleroderma patients and age-stratified general practice controls.
A pre-piloted telephone questionnaire collected data on augmentation mammoplasty, symptom onset, and diagnosis dates.
Socioeconomically adjusted rate ratios were calculated for comparisons.

Main Results:

Augmentation mammoplasty rates were similar between interviewed scleroderma cases and controls.
No augmentation mammoplasty was found in the medical records of deceased scleroderma patients.
Rates of non-mammoplasty silicone exposure, mastectomy, and lumpectomy were comparable across groups.

Conclusions:

The study did not find evidence supporting an association between silicone breast implantation and the development of scleroderma.
The findings indicate no increased risk of scleroderma following augmentation mammoplasty within the study's power limitations.

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