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2-(Methyleneaminoxy)methylmorpholine derivatives. Synthesis and antidepressant activity
A Balsamo1, A Lapucci, M Macchia
1Istituto di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Pisa, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|February 1, 1994
Summary
New antidepressant drug analogues, 3-(methyleneaminoxy)methylmorpholines, were synthesized and tested. Some compounds showed a pharmacological profile similar to the antidepressant viloxazine.
Area of Science:
- Medicinal Chemistry
- Pharmacology
Background:
- Viloxazine is an established antidepressant drug.
- Novel analogues were designed to explore structure-activity relationships.
Purpose of the Study:
- To synthesize novel morpholine derivatives as potential antidepressant agents.
- To evaluate the pharmacological profile of these new compounds.
Main Methods:
- Synthesis of 3-(methyleneaminoxy)methylmorpholine analogues.
- In vivo testing for antagonism of reserpine-induced hypothermia in mice.
- In vitro and in vivo evaluation of anticholinergic, antihistaminic, and anti-adrenaline toxicity effects.
Main Results:
- Several synthesized compounds exhibited antidepressant-like activity.
- Some analogues demonstrated a pharmacological profile comparable to viloxazine.
- Anticholinergic, antihistaminic, and anti-adrenaline toxicity effects were assessed.
Conclusions:
- The synthesized 3-(methyleneaminoxy)methylmorpholine compounds represent promising antidepressant candidates.
- These analogues share a similar pharmacological profile with viloxazine, suggesting potential therapeutic value.