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Hair cycle and alopecia

M Courtois1, G Loussouarn, C Hourseau

  • 1L'Oréal Laboratories RAD, Clichy, France.

Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
|January 1, 1994
PubMed
Summary

Male pattern alopecia involves changes in hair cycle duration, leading to increased hair loss. This study details how shorter anagen phases and reduced hair diameter contribute to thinning hair over time.

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Area of Science:

  • Dermatology
  • Trichology

Background:

  • Male pattern alopecia is a common condition characterized by changes in hair cycle dynamics.
  • Understanding these changes is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the modifications in hair cycle duration, succession, and frequency in male subjects with and without alopecia.
  • To provide a detailed picture of the alopecia condition through long-term observation.

Main Methods:

  • Longitudinal study over 15 years.
  • Phototrichogram analysis of nearly 10,000 hair cycles in 10 male subjects.
  • Inclusion of subjects with varying degrees of alopecia.

Main Results:

  • Observed a decrease in anagen hair duration, correlating with alopecia severity.
  • Documented a parallel decline in hair diameter.
  • Identified longer latency periods between hair shedding and regrowth, reducing scalp hair density.

Conclusions:

  • Male pattern alopecia is characterized by premature anagen to telogen transformation, increased hair loss rate, and reduced hair diameter.
  • Longer periods of hair absence contribute significantly to the visible effects of alopecia.
  • These findings offer insights into the progression of male pattern baldness.

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