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Subclinical intestinal malabsorption in developing countries

S J Baker

    Bulletin of the World Health Organization
    |January 1, 1976
    PubMed
    Summary
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    A common asymptomatic small intestinal disease in developing countries shows structural and functional abnormalities. Its unknown cause is linked to environmental exposure, potentially impacting nutrition on limited diets.

    Area of Science:

    • Gastroenterology and Nutrition Science

    Background:

    • Asymptomatic small intestinal disease with structural and functional abnormalities is prevalent in developing nations.
    • Observed changes include altered villus architecture and microscopic appearance.

    Purpose of the Study:

    • To summarize the structural and functional characteristics of asymptomatic small intestinal disease.
    • To highlight the unknown etiology and potential nutritional implications.

    Main Methods:

    • Review of reported cases detailing structural and functional changes.
    • Microscopic examination (light and electron microscopy) of intestinal tissues.
    • Assessment of nutrient absorption (xylose, fat, vitamin B12, amino acids, dipeptides) and fecal losses (nitrogen, energy).

    Main Results:

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    • Structural abnormalities involve villus architecture and microscopic features.
    • Functional deficits include impaired absorption of various nutrients and increased fecal losses.
    • The condition's etiology remains unknown, though environmental exposure is implicated.

    Conclusions:

    • The disease presents with significant structural and functional small intestinal changes.
    • Environmental factors are suspected contributors to the etiology.
    • Nutritional consequences, especially for vulnerable populations, require further investigation.