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[Is chorionic biopsy a dangerous and outdated method?]

Z Hájek1, E Kulovaný, M Macek

  • 1I. gynek.-porod. klinika 1. LF UK, Praha.

Ceska Gynekologie
|April 1, 1994
PubMed
Summary
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Chorionic villus sampling (CVS) is a safe prenatal diagnostic method with abortion risks comparable to amniocentesis. This study found no limb deformities in infants born after CVS and a low mosaicism rate.

Area of Science:

  • Obstetrics and Gynecology
  • Medical Genetics
  • Fetal Medicine

Context:

  • Prenatal diagnosis is crucial for identifying fetal abnormalities.
  • Chorionic villus sampling (CVS) is an early invasive diagnostic procedure.
  • Assessing the safety and efficacy of CVS is essential for clinical practice.

Purpose:

  • To evaluate the risks associated with chorionic villus sampling (CVS) for prenatal diagnosis.
  • To compare the abortion rates of CVS with amniocentesis.
  • To assess the incidence of limb deformities and mosaicism following CVS.

Summary:

  • Transabdominal CVS demonstrated an abortion incidence of 0.6%, similar to second-trimester amniocentesis (0.5%).
  • No reduction deformities of extremities were observed in 1002 infants following CVS.

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  • The study recorded a mosaicism incidence of 1.59%, not significantly higher than literature values.
  • CVS is recommended for prenatal diagnosis before 20 weeks gestation, especially when cordocentesis poses risks, with suggestions for optimizing tissue sample size.

    • Impact:

    • Provides evidence supporting the safety of CVS as a prenatal diagnostic tool.
    • Informs clinical decision-making regarding the timing and method of fetal genetic testing.
    • Contributes to the understanding of potential risks and benefits of early invasive prenatal procedures.