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Updated: Feb 16, 2026

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
Published on: August 26, 2025
[Effects of left bundle branch block on pulmonary vein and transmitral flow]
A V Mattioli1, E Casali, D Vivoli
1Cattedra di Cardiologia, Università degli Studi, Modena.
Insights
Left bundle branch block (LBBB) from ventricular pacing impairs left ventricular function, altering pulmonary venous flow (PVF) and mitral flow (MF). Atrial contraction plays a more significant role in ventricular function with LBBB.
Area of Science:
- Cardiology
- Cardiac Electrophysiology
- Echocardiography
Background:
- Left ventricular function is crucial for cardiac performance.
- Left bundle branch block (LBBB) is known to affect ventricular function.
- Doppler evaluation of pulmonary venous flow (PVF) and mitral flow (MF) can assess left ventricular function.
Purpose of the Study:
- To investigate the impact of LBBB induced by ventricular pacing on cardiac performance.
- To evaluate changes in PVF and MF during LBBB.
Main Methods:
- Transesophageal echocardiography (TEE) was performed in 10 patients with sick sinus syndrome (SSS) on permanent VDD pacing.
- PVF and MF were assessed during sinus rhythm and ventricular pacing (inducing LBBB).
Main Results:
- Ventricular pacing-induced LBBB increased reversal flow in pulmonary veins during atrial contraction.
- Diastolic PVF increased during cardiac pacing.
- Mitral flow (MF) showed prolonged deceleration time.
Conclusions:
- LBBB induced by ventricular pacing is associated with reduced left ventricular function.
- Atrial contraction contributes more significantly to ventricular function in the presence of LBBB.
Abstract:
Doppler evaluation of pulmonary venous flow (PVF) and of mitral flow (MF) can be useful to understand left ventricular function. It is well known that left bundle branch block (LBBB) can influence ventricular function. The aim of the present study was to evaluate the role of LBBB induced by ventricular pacing on cardiac performance. We performed transesophageal echocardiography (TEE) in 10 patients affected by sick sinus syndrome (SSS) treated with a permanent pacemaker (VDD modality). We evaluated PVF and MF and compared the pattern from the same patients in sinus rhythm and during cardiac pacing. We observed an increase in the reversal flow in the pulmonary vein during atrial contraction. The diastolic flow of pulmonary vein increased during cardiac pacing. The MF showed an increase in deceleration time. Our results suggest that LBBB is associated with a reduction in ventricular function. This phenomenon induce a higher contribution of atrial contraction to ventricular function.
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