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Platinum and palladium complexes containing ethylenediamine derivatives as carrier ligands and their antitumor
1Department of Pharmacy, Graduate School, Sookmyung Women's University Seoul, Korea.
Chemical & Pharmaceutical Bulletin
|March 1, 1994
Abstract:
We prepared new antitumor active platinum complexes containing N,N'-bis(2-chloroethyl)ethylenediamine (ClEn) as an alkylating carrier ligand in order to obtain increased antitumor effects. Some of the platinum complexes synthesized showed enhanced antitumor activity. However, palladium(II) complexes containing ClEn were inactive against L1210 and P388.