Complex patterns of [125I]omega-conotoxin GVIA binding site expression during postnatal rat brain development
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F Filloux1, A Schapper, S R Naisbitt
1Department of Neurology, University of Utah, Salt Lake City 84132.
Brain Research. Developmental Brain Research
|March 18, 1994
Abstract:
In the mature CNS, N-type calcium channels regulate neurotransmitter release. The role of these channels in developing brain is less clear. Study of [125I]omega-conotoxin GVIA binding sites in developing rat brain using autoradiography reveals that putative N-type channels appear and disappear in complex temporal-spatial profiles including: (1) gradual increase to adult levels (cerebral cortex); (2) substructure differentiation (cerebellum); (3) transient expression (pons); and, (4) selective depletion (medulla). Transient expression of N-type calcium channels may influence specific neurodevelopmental processes.