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Updated: Aug 8, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
Idiopathic dilated cardiomyopathy
A J Hackel1, G Wagner, D B Hackel
1Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Insights
This case study examines a 43-year-old man with a 9-year history of congestive heart failure. Autopsy revealed biventricular dilatation, suggesting viral or alcoholic cardiomyopathy as potential causes.
Area of Science:
- Cardiology
- Pathology
Background:
- Congestive heart failure (CHF) is a complex clinical syndrome.
- Long-term heavy alcohol use and viral infections are known risk factors for cardiac disease.
Abstract:
A 43-year-old man had a 9-year history of congestive heart failure manifested by an enlarged heart and symptoms of shortness of breath and chest discomfort. Heart failure had been preceded by a "viral illness" and he had been a heavy alcohol user until that time. Autopsy showed congestion and edema characteristic of heart failure and cardiomegaly with biventricular dilatation. Either viral or alcoholic disease, or both, could have been the cause of the cardiac problems.
Related Concept Videos
Myocarditis I: Introduction
Cardiomyopathy I: Introduction and Classification
Cardiomyopathy II: Dilated Cardiomyopathy
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiomyopathy IV: Restrictive Cardiomyopathy
Cardiomyopathy V: Interprofessional Care

