Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malignancy-induced secondary achalasia

H P Parkman1, S Cohen

  • 1Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.

Dysphagia
|January 1, 1994
PubMed
Summary

Secondary achalasia, often caused by cancer, presents with dysphagia. Key indicators include short symptom duration, weight loss, and age over 55, prompting further investigation for malignancy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pyloric sphincter characteristics using EndoFLIP<sup>®</sup> in gastroparesis.

Revista de gastroenterologia de Mexico (English)·2018
Same author

Therapeutic response to domperidone in gastroparesis: A prospective study using the GCSI-daily diary.

Neurogastroenterology and motility·2017
Same author

Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis.

Neurogastroenterology and motility·2017
Same author

Gastroesophageal reflux disease-related symptom recurrence in patients discontinuing proton pump inhibitors for Bravo<sup>®</sup> wireless esophageal pH monitoring study.

Revista de gastroenterologia de Mexico·2017
Same author

Gastric neuromuscular histology in patients with refractory gastroparesis: Relationships to etiology, gastric emptying, and response to gastric electric stimulation.

Neurogastroenterology and motility·2017
Same author

Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum.

Neurogastroenterology and motility·2017

Area of Science:

  • Gastroenterology
  • Oncology
  • Radiology

Background:

  • Secondary achalasia develops due to an underlying disorder, frequently malignancy.
  • Adenocarcinoma of the esophagogastric junction is the most common cause of malignancy-induced achalasia.
  • Noncontiguous tumors can also lead to secondary achalasia.

Purpose of the Study:

  • To highlight the importance of recognizing malignancy-induced secondary achalasia.
  • To inform gastroenterologists and radiologists about key diagnostic features.
  • To emphasize the need for prompt diagnosis and treatment of the underlying neoplasm.

Main Methods:

  • Review of clinical, radiographic, and manometric findings associated with secondary achalasia.
  • Identification of clinical features suggesting malignancy: short dysphagia duration (< 1 year), significant weight loss (> 15 pounds), and age > 55 years.
  • Discussion of diagnostic modalities including esophagrams, endoscopy, thoraco-abdominal CT scanning, and endoscopic ultrasonography.

Main Results:

  • Malignancy is a recognized, though rare, cause of secondary achalasia.
  • Specific clinical features (short dysphagia duration, weight loss, older age) raise suspicion for malignancy.
  • Standard diagnostic methods may not suffice, necessitating advanced imaging.

Conclusions:

  • Recognizing secondary achalasia is crucial for identifying underlying malignancies.
  • Clinical suspicion based on specific features is vital for timely diagnosis.
  • Advanced imaging techniques are essential when malignancy is suspected.

Related Experiment Videos